Publications

Mapping intratumor heterogeneity across layers for advancing immunotherapy - Marine JC, Bartok O, Sagie S, Vitiello PP, Bardelli A, Weller C, Chang T-G, Tonelli C, Spranger S, Ruppin E, Samuels Y - 2026 - Cell - Pubmed 

A Physical Framework to Control Cancer Cell Heterogeneity and Plasticity - De Blander H, Marine JC - 2026 - Cancer Discovery - Pubmed

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma - Karakousi T, Cristaldi V, Lopes de Oliveira ML, Delclaux I, Besson NR, Geraldo LH, González-Robles TJ, McDonnough DR, Martinez-Krams D, da Silva G, Breazeale AP, Encarnacion-Rosado J, Pozniak J, Qiu S, Illa Bochaca I, Kaiza ME, Kim HM, Bruno TC, Reizis B, Moshiri AS, Kimmelman AC, Ruggles KV, Osman I, Marine JC, Chandel NS, Lund AW - 2026 - Cancer Cell - Pubmed 

Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy - Baures M, Vieira Aleixo A-S, Pacreau E, Koshy A, Friedrich V, Diedisheim M, Raigel M, Hua Y, Dariane C, Boutillon F, Kenner L, Marine JC, Laverny G, Metzger D, Rambow F, Guidotti J-E, Goffin V.- 2026 - EMBO Mol Med - Pubmed 

Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype - Pozniak J, Roda N, Landeloos E, Antoranz A, Van Herck Y, De Visscher A, Demaerel PG, Vanwynsberghe L, Declercq J, Gkemisis C, Bervoets G, Song N-J, Bassez Ayse, Browaeys R, Pollaris L, Bosisio FM, Boecxstaens V, Saeys Y, Lambrechts D, Li Z, Matthys P, Bechter O, Marine J-C - 2025 - Cancer Discovery - Pubmed

Tumor-associated NK Cells Regulate Distinct CD8⁺ T-cell Differentiation Program in Cancer and Contribute to Resistance against Immune Checkpoint Blockers - Song N-J, Xie J, Jung KJ, Wang Y, Pozniak J, Roda N, Marine JC, Riesenberg BP, Jeon H, Ma A, Cox N, Wethington D, Reynolds K, Xiao T, Li A, Kronen P, Denko N, Carbone DP, Ma Q, Carson WE, Mundy-Bosse BL, Burd CE, Das J, Chung D, Li Z - 2025 - Cancer Discovery - Pubmed 

Fishing for melanoma metastasis-initiating cells in lymph nodes: Metastasis - Karras P, Marine J-C - 2025 - Nature Cancer - Pubmed

Decoding melanoma's cellular mosaic to unlock immunotherapy potential - Pozniak J, Marine J-C - 2025 - Trends Cell Biol - Pubmed 

Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment - Lodi F, Vanmassenhove S, Chen D, Boeckx B, Maciel LF, Peeters F, Donders E, Song H, Harbers L, Pozniak J, Loverix L, Zhou Y, Bila M, Bassez A, Cappuyns S, Venken T, Olbrecht S, Franken A, Van Mol P, Schepers R, van Brussel T, Philips G, Vos H, Keupers M, De Smet F, Tejpar S, Bechter O, Bergers G, Smeets A, Clement P, Wauters E, Dekervel J, Van Gorg T, Qian J, Marine J-C, Lambrechts D - 2025 - Cell Rep Med. - Pubmed 

Single-cell mapping of alternative splicing linked to checkpoint immunotherapy response - Xiong J, Bricard O, Arijs I, Demeulemeester J, Gu C, Theinpont B, Daaboul D, Bassez A, Bechter O, Pozniak J, Vos H, Nevelsteen I, Torfs S, Santos SA, Lan Q, Hou Y, Van oudenhove L, Boons G, Qian J, Aerts S, Smeets A, Marine J-C, Lambrechts D - 2025 - Nucleic Acids Res. - Pubmed

AMP-activated protein kinase-driven lipid droplet dynamics govern melanoma sensitivity to polyunsaturated fatty acid and iron-induced ferroptosis - Motamedi S, Rvoet N, Dehairs J, Vanderhoydonc F, Escamilla-Ayala A, Sliwinska MA, Wang S, Idkowiak J, Soenen S, Agostinis P, Marine J-C, Swinnen JV - 2025 - Nat Commun. - Pubmed

Decoding the interplay between genetic and non-genetic drivers of metastasis - Karras P, Black JRM, McGranahan N, Marine J-C - 2024 - Nature - Pubmed 
 

Cell States in Cancer: Drivers, Passengers, and Trailers - Gargiulo G, Serresi M, Marine J-C - 2024 - Cancer Discovery - Pubmed 

A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma - Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, Nowosad A, Roda N, Makhzami S, Bervoets G, Maciel LF, Pulido-Vicuña CA, Pollaris L, Seurinck R, Zhao F, Flem-Karlsen K, Damsky W, Chen L, Karagianni D, Cinque S, Kint S, Vandereyken K, Rombaut B, Voet T, Vernaillen F, Annaert W, Lambrechts D, Boecxstaens V, Saeys Y, van den Oord J, Bosisio F, Karras P, Shain AH, Bosenberg M, Leucci E, Paschen A, Rambow F, Bechter O, Marine J-C - 2024 - Cell - Pubmed
 

Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy - Talebi A, de Laat V, Spotbeen X, Dehairs J, Rambow F, Rogiers A, Vanderhoydonc F, Rizotto L, Planque M, Doglioni G, Motamedi S, Nittner D, Roskams T, Agostinis P, Bechter O, Boecxstaens V, Garmyn M, O'Farrell M, Wagman A, Kemble G, Leucci E, Fendt SM, Marine JC, Swinnen JV. - 2023 - J Exp Clin Cancer - Pubmed

Perivascular niches: critical hubs in cancer evolution - Nowosad A, Marine JC, Karras P. - 2023 - Trends Cancer - Pubmed

A cellular hierarchy in melanoma uncouples growth and metastasis - Karras P, Bordeu I, Pozniak J, Nowosad A, Pazzi C, Van Raemdonck N, Landeloos E, Van Herck Y, Pedri D, Bervoets G, Makhzami S, Khoo JH, Pavie B, Lamote J, Marin-Bejar O, Dewaele M, Liang H, Zhang X, Hua Y, Wouters J, Browaeys R, Bergers G, Saeys Y, Bosisio F, van den Oord J, Lambrechts D, Rustgi AK, Bechter O, Blanpain C, Simons BD, Rambow F, Marine JC - 2022 - Nature - Pubmed

A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma -  Pozniak J,  Pedri D, Landeloos E, Van Herck Y,  Antoranz A,  Karras P,  Nowosad A, Makhzami S,  Bervoets G,  Dewaele M,  Vanwynsberghe L, Cinque S, Kint S,  Vandereyken K,  Voet T,  Vernaillen F, Annaert W,  Lambrechts D,  Boecxstaens V, van den Oord J, Bosisio F,  Leucci E, Rambow F, Bechter O,  Marine JC - 2022 - BioRxiv

Treatment for giant congenital nevi moves a step closer - Pozniak J, Marine JC - 2022 - Cell Res. - Pubmed

Cell position matters in tumour development - Marine JC, Soengas MS - 2022 - Nature - Pubmed

Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma - Vendramin R, Katopodi V, Cinque S, Konnova A, Knezevic Z, Adnane S, Verheyden Y, Karras P, Demesmaeker E, Bosisio FM, Kucera L, Rozman J, Gladwyn-Ng I, Rizzotto L, Dassi E, Millevoi S, Bechter O, Marine JC, Leucci E. - J Exp Med. - Pubmed

Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma - Marin-Bejar O, Rogiers A, Dewaele M, Femel J, Karras P, Pozniak J, Bervoets G, Van Raemdonck N, Pedri D, Swings T, Demeulemeester J, Borght SV, Lehnert S, Bosisio F, van den Oord JJ, Bempt IV, Lambrechts D, Voet T, Bechter O, Rizos H, Levesque MP, Leucci E, Lund AW, Rambow F, Marine JC - Cancer Cell - Pubmed

Epithelial-to-mesenchymal-like transition events in melanoma - Pedri D, Karras P, Landeloos E, Marine JC, Rambow F - FEBS J - Pubmed

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1 - Barra J, Gaidosh GS, Blumenthal Ezra, Beckedorff F, Tayari MM, Kirstein N, Karakach TK, Heick Jensen T, Impens F, Gevaert K, Leucci E, Shiekhattar R and Marine JC - Science Adv - Pubmed

Non-Genetic Mechanisms of Therapeutic Resistance in Cancer - Marine JC, Dawson SJ and Dawson MA - Nat Rev Cancer - Pubmed

Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities - Rambow F, Marine J-C* & Goding C* - Genes & Dev - Pubmed

The lncRNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth - Adriaens C, Rambow F, Bervoets G, Silla T, Mito M, Chiba T, Hiroshi A, Hirose T, Nakagawa S, Jensen T and Marine JC - RNA - Pubmed

Toward Minimal Residual Disease-Directed Therapy in Melanoma - Rambow F., Rogiers A, Aibar S, Dewaele M, Marin-Bejar O, Adriaens C, Talebi A, Wouters J, Radaelli E, Wolter P, Bechter O, Piris A, Frederick DT, Boland G, Flaherty KT, van den Oord JJ, Aerts S & Marine JC - 2018 - Cell - Pubmed

Identification of the tumour transition states occurring during EMT - Pastushenko I, Brisebarre A, Sifrim A, Fioramonti M, Renvenco T, Boumahdi S, Van Keymeulen A, Brown D, Moers V, Lemaire S, de Clercq S, Minguijon-Perez E, Balsat C, Sokolow S, Dubois C, de Cock F, Scozzaro S, Lanas A, D’Haene N, Salmon I, Marine JC, Voet T, Sotiropoulou P & Blanpain C - 2018 - Nature - Pubmed

Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes - Köhler C, Nittner D, Rambow F, Radaelli E, Stanchi F, Niels Vandamme N, Baggiolini A, Sommer L, Berx G, van den Oord J, Gerhardt H, Blanpain C & Marine JC - 2017 - Cell Stem Cell - Pubmed

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity - Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, Boeckx B, Wijnhoven PW, Radaelli E, Vermi W, Leucci E, Lapouge G, Beck B, van den Oord J, Nakagawa S, Hirose T, Sablina AA, Lambrechts D, Aerts S, Blanpain C, Marine JC - 2016 - Nat Med - Pubmed

Melanoma Addiction to the lncRNA SAMMSON - Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Venderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine D, Gevaert K, Vandesompele Jo, Mestdagh P, & Marine JC - 2016 - Nature - Pubmed
 

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation - Nittner D, Lambertz I, Clermont F, Mestdagh P, Köhler C, Nielsen SJ, Jochemsen A, Speleman F, Vandesompele J, Dyer MA, Schramm A, Schulte JH, Marine JC - 2012 - Nat Cell Biol - Pubmed

MDM4 is a key therapeutic target in cutaneous melanoma - Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi H, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC - 2012 - Nat Med - Pubmed